| 1 | FC Cincinnati | 34 | 23 | 8 | 3 | 72:34 | 77 | Gy Gy Gy D D |
| 2 | Louisville City FC | 34 | 19 | 9 | 6 | 71:38 | 66 | Gy Gy Gy Gy Gy |
| 3 | Pittsburgh Riverhounds | 34 | 15 | 14 | 5 | 47:26 | 59 | Gy D D D V |
| 4 | Charleston Battery | 34 | 14 | 14 | 6 | 47:34 | 56 | D Gy V V Gy |
| 5 | New York Red Bulls II | 34 | 13 | 13 | 8 | 71:59 | 52 | D D Gy Gy Gy |
| 6 | Philadelphia Union II | 34 | 14 | 8 | 12 | 56:41 | 50 | V Gy D D Gy |
| 7 | Indy Eleven | 34 | 13 | 10 | 11 | 45:42 | 49 | V Gy V D V |
| 8 | Nashville SC | 34 | 12 | 13 | 9 | 42:31 | 49 | Gy D Gy D D |
| 9 | North Carolina FC | 34 | 13 | 8 | 13 | 60:50 | 47 | V Gy V V Gy |
| 10 | Ottawa Fury | 34 | 13 | 6 | 15 | 31:43 | 45 | Gy V Gy D V |
| 11 | Charlotte Independence | 34 | 10 | 12 | 12 | 44:57 | 42 | D D D Gy V |
| 12 | Tampa Bay Rowdies | 34 | 11 | 8 | 15 | 44:44 | 41 | Gy V D V V |
| 13 | Penn FC | 34 | 9 | 10 | 15 | 38:47 | 37 | V V D V D |
| 14 | Atlanta United II | 34 | 7 | 10 | 17 | 37:72 | 31 | V D Gy D Gy |
| 15 | Richmond Kickers | 34 | 6 | 4 | 24 | 30:80 | 22 | V V V V V |
| 16 | Toronto FC II | 34 | 4 | 6 | 24 | 42:77 | 18 | V Gy V D D |
| 1 | FC Cincinnati | 34 | 23 | 8 | 3 | 72:34 | 77 | Gy Gy Gy D D |
| 2 | Orange County SC | 34 | 20 | 6 | 8 | 70:40 | 66 | Gy Gy Gy Gy V |
| 3 | Louisville City FC | 34 | 19 | 9 | 6 | 71:38 | 66 | Gy Gy Gy Gy Gy |
| 4 | Sacramento Republic | 34 | 19 | 8 | 7 | 47:32 | 65 | D Gy Gy Gy Gy |
| 5 | Phoenix Rising FC | 34 | 19 | 6 | 9 | 63:38 | 63 | Gy Gy D V V |
| 6 | Real Monarchs SLC | 34 | 19 | 3 | 12 | 55:47 | 60 | V V V Gy Gy |
| 7 | Reno 1868 FC | 34 | 16 | 11 | 7 | 56:38 | 59 | Gy Gy Gy D Gy |
| 8 | Pittsburgh Riverhounds | 34 | 15 | 14 | 5 | 47:26 | 59 | Gy D D D V |
| 9 | Charleston Battery | 34 | 14 | 14 | 6 | 47:34 | 56 | D Gy V V Gy |
| 10 | Portland Timbers II | 34 | 17 | 4 | 13 | 58:49 | 55 | Gy D V V Gy |
| 11 | Sporting Kansas City II | 34 | 15 | 8 | 11 | 52:53 | 53 | V Gy D V Gy |
| 12 | Saint Louis FC | 34 | 14 | 11 | 9 | 44:38 | 53 | Gy Gy V Gy D |
| 13 | New York Red Bulls II | 34 | 13 | 13 | 8 | 71:59 | 52 | D D Gy Gy Gy |
| 14 | Philadelphia Union II | 34 | 14 | 8 | 12 | 56:41 | 50 | V Gy D D Gy |
| 15 | San Antonio FC | 34 | 14 | 8 | 12 | 45:48 | 50 | V V Gy Gy D |
| 16 | Indy Eleven | 34 | 13 | 10 | 11 | 45:42 | 49 | V Gy V D V |
| 17 | Nashville SC | 34 | 12 | 13 | 9 | 42:31 | 49 | Gy D Gy D D |
| 18 | North Carolina FC | 34 | 13 | 8 | 13 | 60:50 | 47 | V Gy V V Gy |
| 19 | Ottawa Fury | 34 | 13 | 6 | 15 | 31:43 | 45 | Gy V Gy D V |
| 20 | OKC Energy FC | 34 | 12 | 7 | 15 | 43:46 | 43 | Gy D Gy V D |
| 21 | Charlotte Independence | 34 | 10 | 12 | 12 | 44:57 | 42 | D D D Gy V |
| 22 | Tampa Bay Rowdies | 34 | 11 | 8 | 15 | 44:44 | 41 | Gy V D V V |
| 23 | Colorado Switchbacks FC | 34 | 11 | 6 | 17 | 36:39 | 39 | D V Gy V D |
| 24 | Fresno FC | 34 | 9 | 12 | 13 | 44:38 | 39 | V D V Gy V |
| 25 | Rio Grande Valley FC Toros | 34 | 8 | 14 | 12 | 36:42 | 38 | Gy V Gy Gy D |
| 26 | Ventura County FC | 34 | 10 | 7 | 17 | 60:67 | 37 | V Gy D V V |
| 27 | Penn FC | 34 | 9 | 10 | 15 | 38:47 | 37 | V V D V D |
| 28 | Las Vegas Lights FC | 34 | 8 | 7 | 19 | 50:74 | 31 | V V V Gy V |
| 29 | Atlanta United II | 34 | 7 | 10 | 17 | 37:72 | 31 | V D Gy D Gy |
| 30 | Tacoma Defiance | 34 | 6 | 7 | 21 | 40:71 | 25 | V D V D Gy |
| 31 | Richmond Kickers | 34 | 6 | 4 | 24 | 30:80 | 22 | V V V V V |
| 32 | Tulsa | 34 | 3 | 12 | 19 | 36:77 | 21 | D V V V V |
| 33 | Toronto FC II | 34 | 4 | 6 | 24 | 42:77 | 18 | V Gy V D D |
| 1 | Orange County SC | 34 | 20 | 6 | 8 | 70:40 | 66 | Gy Gy Gy Gy V |
| 2 | Sacramento Republic | 34 | 19 | 8 | 7 | 47:32 | 65 | D Gy Gy Gy Gy |
| 3 | Phoenix Rising FC | 34 | 19 | 6 | 9 | 63:38 | 63 | Gy Gy D V V |
| 4 | Real Monarchs SLC | 34 | 19 | 3 | 12 | 55:47 | 60 | V V V Gy Gy |
| 5 | Reno 1868 FC | 34 | 16 | 11 | 7 | 56:38 | 59 | Gy Gy Gy D Gy |
| 6 | Portland Timbers II | 34 | 17 | 4 | 13 | 58:49 | 55 | Gy D V V Gy |
| 7 | Saint Louis FC | 34 | 14 | 11 | 9 | 44:38 | 53 | Gy Gy V Gy D |
| 8 | Sporting Kansas City II | 34 | 15 | 8 | 11 | 52:53 | 53 | V Gy D V Gy |
| 9 | San Antonio FC | 34 | 14 | 8 | 12 | 45:48 | 50 | V V Gy Gy D |
| 10 | OKC Energy FC | 34 | 12 | 7 | 15 | 43:46 | 43 | Gy D Gy V D |
| 11 | Colorado Switchbacks FC | 34 | 11 | 6 | 17 | 36:39 | 39 | D V Gy V D |
| 12 | Fresno FC | 34 | 9 | 12 | 13 | 44:38 | 39 | V D V Gy V |
| 13 | Rio Grande Valley FC Toros | 34 | 8 | 14 | 12 | 36:42 | 38 | Gy V Gy Gy D |
| 14 | Ventura County FC | 34 | 10 | 7 | 17 | 60:67 | 37 | V Gy D V V |
| 15 | Las Vegas Lights FC | 34 | 8 | 7 | 19 | 50:74 | 31 | V V V Gy V |
| 16 | Tacoma Defiance | 34 | 6 | 7 | 21 | 40:71 | 25 | V D V D Gy |
| 17 | Tulsa | 34 | 3 | 12 | 19 | 36:77 | 21 | D V V V V |