| 1 | Tampa Bay Rowdies | 32 | 23 | 2 | 7 | 55:23 | 71 | P R V V V |
| 2 | Charlotte Independence | 32 | 18 | 5 | 9 | 57:36 | 59 | V V V V R |
| 3 | Pittsburgh Riverhounds | 32 | 16 | 8 | 8 | 51:34 | 56 | P V R V R |
| 4 | Miami FC | 32 | 16 | 7 | 9 | 55:39 | 55 | P R P V V |
| 5 | Hartford Athletic | 32 | 12 | 5 | 15 | 50:50 | 41 | V V P V R |
| 6 | Charleston Battery | 32 | 10 | 7 | 15 | 49:60 | 37 | P V P P P |
| 7 | New York Red Bulls II | 32 | 7 | 7 | 18 | 42:67 | 28 | P R V P V |
| 8 | Loudoun United FC | 32 | 4 | 3 | 25 | 31:78 | 15 | P P P P P |
| 1 | Louisville City FC | 32 | 18 | 7 | 7 | 61:37 | 61 | V P P V V |
| 2 | Birmingham Legion FC | 32 | 18 | 6 | 8 | 51:31 | 60 | V V R V P |
| 3 | Memphis 901 FC | 32 | 14 | 8 | 10 | 47:42 | 50 | V V P V V |
| 4 | Tulsa | 32 | 14 | 5 | 13 | 49:48 | 47 | R V R P V |
| 5 | OKC Energy FC | 32 | 8 | 13 | 11 | 30:38 | 37 | P R R P P |
| 6 | Indy Eleven | 32 | 9 | 8 | 15 | 32:47 | 35 | R P V R P |
| 7 | Atlanta United II | 32 | 7 | 10 | 15 | 44:57 | 31 | R R P P P |
| 8 | Sporting Kansas City II | 32 | 5 | 8 | 19 | 34:61 | 23 | P P V P P |
| 1 | Tampa Bay Rowdies | 32 | 23 | 2 | 7 | 55:23 | 71 | P R V V V |
| 2 | Louisville City FC | 32 | 18 | 7 | 7 | 61:37 | 61 | V P P V V |
| 3 | Birmingham Legion FC | 32 | 18 | 6 | 8 | 51:31 | 60 | V V R V P |
| 4 | Charlotte Independence | 32 | 18 | 5 | 9 | 57:36 | 59 | V V V V R |
| 5 | Pittsburgh Riverhounds | 32 | 16 | 8 | 8 | 51:34 | 56 | P V R V R |
| 6 | Miami FC | 32 | 16 | 7 | 9 | 55:39 | 55 | P R P V V |
| 7 | Memphis 901 FC | 32 | 14 | 8 | 10 | 47:42 | 50 | V V P V V |
| 8 | Tulsa | 32 | 14 | 5 | 13 | 49:48 | 47 | R V R P V |
| 9 | Hartford Athletic | 32 | 12 | 5 | 15 | 50:50 | 41 | V V P V R |
| 10 | OKC Energy FC | 32 | 8 | 13 | 11 | 30:38 | 37 | P R R P P |
| 11 | Charleston Battery | 32 | 10 | 7 | 15 | 49:60 | 37 | P V P P P |
| 12 | Indy Eleven | 32 | 9 | 8 | 15 | 32:47 | 35 | R P V R P |
| 13 | Atlanta United II | 32 | 7 | 10 | 15 | 44:57 | 31 | R R P P P |
| 14 | New York Red Bulls II | 32 | 7 | 7 | 18 | 42:67 | 28 | P R V P V |
| 15 | Sporting Kansas City II | 32 | 5 | 8 | 19 | 34:61 | 23 | P P V P P |
| 16 | Loudoun United FC | 32 | 4 | 3 | 25 | 31:78 | 15 | P P P P P |
| 1 | El Paso Locomotive FC | 32 | 18 | 10 | 4 | 56:34 | 64 | V P V V P |
| 2 | San Antonio FC | 32 | 14 | 10 | 8 | 50:38 | 52 | V R P R V |
| 3 | Colorado Switchbacks FC | 32 | 13 | 10 | 9 | 60:50 | 49 | R P V R P |
| 4 | Rio Grande Valley FC Toros | 32 | 13 | 8 | 11 | 49:42 | 47 | R P V V V |
| 5 | New Mexico United | 32 | 12 | 10 | 10 | 44:40 | 46 | R R V P V |
| 6 | Austin Bold FC | 32 | 10 | 12 | 10 | 32:42 | 42 | P P P R R |
| 7 | Real Monarchs SLC | 32 | 5 | 7 | 20 | 28:56 | 22 | R V R P P |
| 1 | Phoenix Rising FC | 32 | 20 | 7 | 5 | 68:35 | 67 | V P V R R |
| 2 | Orange County SC | 32 | 15 | 7 | 10 | 44:37 | 52 | V V V V V |
| 3 | San Diego Loyal | 32 | 14 | 6 | 12 | 51:43 | 48 | V R P P R |
| 4 | Oakland Roots | 32 | 11 | 8 | 13 | 36:43 | 41 | P P R V V |
| 5 | Ventura County FC | 32 | 11 | 6 | 15 | 55:57 | 39 | R V P P P |
| 6 | Tacoma Defiance | 32 | 10 | 9 | 13 | 37:41 | 39 | P R R V R |
| 7 | Sacramento Republic | 32 | 8 | 12 | 12 | 36:42 | 36 | P R R R R |
| 8 | Las Vegas Lights FC | 32 | 6 | 3 | 23 | 41:77 | 21 | P V P P P |
| 1 | Tampa Bay Rowdies | 32 | 23 | 2 | 7 | 55:23 | 71 | P R V V V |
| 2 | Phoenix Rising FC | 32 | 20 | 7 | 5 | 68:35 | 67 | V P V R R |
| 3 | El Paso Locomotive FC | 32 | 18 | 10 | 4 | 56:34 | 64 | V P V V P |
| 4 | Louisville City FC | 32 | 18 | 7 | 7 | 61:37 | 61 | V P P V V |
| 5 | Birmingham Legion FC | 32 | 18 | 6 | 8 | 51:31 | 60 | V V R V P |
| 6 | Charlotte Independence | 32 | 18 | 5 | 9 | 57:36 | 59 | V V V V R |
| 7 | Pittsburgh Riverhounds | 32 | 16 | 8 | 8 | 51:34 | 56 | P V R V R |
| 8 | Miami FC | 32 | 16 | 7 | 9 | 55:39 | 55 | P R P V V |
| 9 | San Antonio FC | 32 | 14 | 10 | 8 | 50:38 | 52 | V R P R V |
| 10 | Orange County SC | 32 | 15 | 7 | 10 | 44:37 | 52 | V V V V V |
| 11 | Memphis 901 FC | 32 | 14 | 8 | 10 | 47:42 | 50 | V V P V V |
| 12 | Colorado Switchbacks FC | 32 | 13 | 10 | 9 | 60:50 | 49 | R P V R P |
| 13 | San Diego Loyal | 32 | 14 | 6 | 12 | 51:43 | 48 | V R P P R |
| 14 | Rio Grande Valley FC Toros | 32 | 13 | 8 | 11 | 49:42 | 47 | R P V V V |
| 15 | Tulsa | 32 | 14 | 5 | 13 | 49:48 | 47 | R V R P V |
| 16 | New Mexico United | 32 | 12 | 10 | 10 | 44:40 | 46 | R R V P V |
| 17 | Austin Bold FC | 32 | 10 | 12 | 10 | 32:42 | 42 | P P P R R |
| 18 | Hartford Athletic | 32 | 12 | 5 | 15 | 50:50 | 41 | V V P V R |
| 19 | Oakland Roots | 32 | 11 | 8 | 13 | 36:43 | 41 | P P R V V |
| 20 | Ventura County FC | 32 | 11 | 6 | 15 | 55:57 | 39 | R V P P P |
| 21 | Tacoma Defiance | 32 | 10 | 9 | 13 | 37:41 | 39 | P R R V R |
| 22 | OKC Energy FC | 32 | 8 | 13 | 11 | 30:38 | 37 | P R R P P |
| 23 | Charleston Battery | 32 | 10 | 7 | 15 | 49:60 | 37 | P V P P P |
| 24 | Sacramento Republic | 32 | 8 | 12 | 12 | 36:42 | 36 | P R R R R |
| 25 | Indy Eleven | 32 | 9 | 8 | 15 | 32:47 | 35 | R P V R P |
| 26 | Atlanta United II | 32 | 7 | 10 | 15 | 44:57 | 31 | R R P P P |
| 27 | New York Red Bulls II | 32 | 7 | 7 | 18 | 42:67 | 28 | P R V P V |
| 28 | Sporting Kansas City II | 32 | 5 | 8 | 19 | 34:61 | 23 | P P V P P |
| 29 | Real Monarchs SLC | 32 | 5 | 7 | 20 | 28:56 | 22 | R V R P P |
| 30 | Las Vegas Lights FC | 32 | 6 | 3 | 23 | 41:77 | 21 | P V P P P |
| 31 | Loudoun United FC | 32 | 4 | 3 | 25 | 31:78 | 15 | P P P P P |
| 32 | North Carolina FC | 0 | 0 | 0 | 0 | 0:0 | 0 | |
| 33 | Philadelphia Union II | 0 | 0 | 0 | 0 | 0:0 | 0 | |
| 34 | Portland Timbers II | 0 | 0 | 0 | 0 | 0:0 | 0 | |
| 35 | Reno 1868 FC | 0 | 0 | 0 | 0 | 0:0 | 0 | |
| 36 | Saint Louis FC | 0 | 0 | 0 | 0 | 0:0 | 0 | |
| 1 | Phoenix Rising FC | 32 | 20 | 7 | 5 | 68:35 | 67 | V P V R R |
| 2 | El Paso Locomotive FC | 32 | 18 | 10 | 4 | 56:34 | 64 | V P V V P |
| 3 | San Antonio FC | 32 | 14 | 10 | 8 | 50:38 | 52 | V R P R V |
| 4 | Orange County SC | 32 | 15 | 7 | 10 | 44:37 | 52 | V V V V V |
| 5 | Colorado Switchbacks FC | 32 | 13 | 10 | 9 | 60:50 | 49 | R P V R P |
| 6 | San Diego Loyal | 32 | 14 | 6 | 12 | 51:43 | 48 | V R P P R |
| 7 | Rio Grande Valley FC Toros | 32 | 13 | 8 | 11 | 49:42 | 47 | R P V V V |
| 8 | New Mexico United | 32 | 12 | 10 | 10 | 44:40 | 46 | R R V P V |
| 9 | Austin Bold FC | 32 | 10 | 12 | 10 | 32:42 | 42 | P P P R R |
| 10 | Oakland Roots | 32 | 11 | 8 | 13 | 36:43 | 41 | P P R V V |
| 11 | Ventura County FC | 32 | 11 | 6 | 15 | 55:57 | 39 | R V P P P |
| 12 | Tacoma Defiance | 32 | 10 | 9 | 13 | 37:41 | 39 | P R R V R |
| 13 | Sacramento Republic | 32 | 8 | 12 | 12 | 36:42 | 36 | P R R R R |
| 14 | Real Monarchs SLC | 32 | 5 | 7 | 20 | 28:56 | 22 | R V R P P |
| 15 | Las Vegas Lights FC | 32 | 6 | 3 | 23 | 41:77 | 21 | P V P P P |